[CAS NO. 894804-07-0] JNK Inhibitor VIII

Name: JNK Inhibitor VIII
Brand: Arctom Scientific
SKU: SLK-S7794

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PRODUCTS SPECIFICATIONS [894804-07-0]

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Catalog

SLK-S7794

Brand

Selleck

CAS

894804-07-0

DESCRIPTION [894804-07-0]

Overview

MDL	MFCD19690908
Molecular Weight	356.38
Molecular Formula	C18H20N4O4
SMILES	O=C(NC1=NC(OCC)=C(C#N)C(N)=C1)CC2=CC(OC)=CC=C2OC

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.8060 mL	14.0300 mL	28.0599 mL
5 mM	0.5612 mL	2.8060 mL	5.6120 mL
10 mM	0.2806 mL	1.4030 mL	2.8060 mL
50 mM	0.0561 mL	0.2806 mL	0.5612 mL

Description

JNK Inhibitor VIII (TCS JNK 6o) is an inhibitor of with IC50 of 45 nM and 160 nM for JNK-1 and JNK-2, respectively. JNK Inhibitor VIII (TCS JNK 6o) inihibits JNK-1, JNK-2, and JNK-3 with Ki of 2 nM, 4 nM and 52 nM, respectively.

Targets

JNK1 ^[1] (Cell-free assay)	JNK2 ^[1] (Cell-free assay)	JNK1 ^[1] (Cell-free assay)	JNK3 ^[1] (Cell-free assay)	JNK2 ^[1] (Cell-free assay)
2 nM(Ki)	4 nM(Ki)	45 nM	52 nM(Ki)	160 nM

In vitro

TCS-JNK-6a binds competitively and reversibly to the ATP site. This compound demonstrates a remarkable selectivity profile. Additionally, it shows some inhibition of c-Jun phosphorylation in hepG2 cells. TCS-JNK-6o is a 2,5-dimethoxy analogue of TCS-JNK-6a with the dimethoxy substitution of the phenyl ring. TCS-JNK-6o shows further gains in potency.

References

[1] Bruce G Szczepankiewicz, et al. J Med Chem. 2006 Jun 15;49(12):3563-80.