[CAS NO. 256373-96-3] MCC950 Sodium (CP-456773 Sodium)
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PRODUCTS SPECIFICATIONS [256373-96-3]
Store
Catalog
SLK-S7809
Brand
Selleck
CAS
256373-96-3
DESCRIPTION [256373-96-3]
Overview
| MDL | MFCD30478884 |
|---|---|
| Molecular Weight | 426.46 |
| Molecular Formula | C20H23N2O5S.Na |
| SMILES | CC(O)(C1=COC(S(=O)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O)=C1)C.[Na+] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3449 mL | 11.7244 mL | 23.4489 mL |
| 5 mM | 0.4690 mL | 2.3449 mL | 4.6898 mL |
| 10 mM | 0.2345 mL | 1.1724 mL | 2.3449 mL |
| 50 mM | 0.0469 mL | 0.2345 mL | 0.4690 mL |
Description
MCC950 Sodium (CP-456773 Sodium, CRID3 sodium salt) is a potent, selective inhibitor of with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
In vitro
MCC950 inhibits canonical and noncanonical NLRP3 activation in BMDM and HMDM cells at IC50 of 7.5 and 8.1nM. MCC950 specifically inhibits activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes.
References
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