[CAS NO. 326914-06-1] MHY1485
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PRODUCTS SPECIFICATIONS [326914-06-1]
Store
Catalog
SLK-S7811
Brand
Selleck
CAS
326914-06-1
DESCRIPTION [326914-06-1]
Overview
| MDL | MFCD00489974 |
|---|---|
| Molecular Weight | 387.39 |
| Molecular Formula | C17H21N7O4 |
| SMILES | O=[N+](C1=CC=C(NC2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C=C1)[O-] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5814 mL | 12.9069 mL | 25.8138 mL |
| 5 mM | 0.5163 mL | 2.5814 mL | 5.1628 mL |
| 10 mM | 0.2581 mL | 1.2907 mL | 2.5814 mL |
| 50 mM | 0.0516 mL | 0.2581 mL | 0.5163 mL |
Description
MHY1485 is a potent, and cell-permeable activator, and also potently inhibits .
Targets
| mTOR [1] |
In vitro
MHY1485 suppresses the basal autophagic flux. MHY1485 causes the accumulation of LC3II and enlargement of the autophagosomes in a dose- and time- dependent manner.MHY1485 increases phospho-mTOR levels and phosphorylation of downstream S6K1 and rpS6 proteins without affecting total mTOR content, total S6K1 and rpS6 levels. Short-term treatment of ovaries with MHY1485 followed by allo-transplantation promoted secondary follicle growth. Treatment with MHY1485 and subsequent grafting allowed the derivation of mature oocytes and healthy offspring.
References
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