[CAS NO. 1334298-90-6] Itacitinib (INCB39110)
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PRODUCTS SPECIFICATIONS [1334298-90-6]
Store
Catalog
SLK-S7812
Brand
Selleck
CAS
1334298-90-6
DESCRIPTION [1334298-90-6]
Overview
| MDL | MFCD28579595 |
|---|---|
| Molecular Weight | 553.51 |
| Molecular Formula | C26H23F4N9O |
| SMILES | N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=CC=NC(C(F)(F)F)=C6F)=O)CC5)C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8067 mL | 9.0333 mL | 18.0665 mL |
| 5 mM | 0.3613 mL | 1.8067 mL | 3.6133 mL |
| 10 mM | 0.1807 mL | 0.9033 mL | 1.8067 mL |
| 50 mM | 0.0361 mL | 0.1807 mL | 0.3613 mL |
Description
Itacitinib(INCB39110) is an orally bioavailable inhibitor of with potential antineoplastic activity.
Targets
| JAK1 [1] |
In vitro
INCB039110 is a potent and selective inhibitor of JAK1, with >20 and >200-fold selectivity over JAK2 and JAK3, respectively. The activity against JAK1, 2, 3, and TYK2 are 2, 63, >2000, and 795 nM, respectively.
References
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