[CAS NO. 866405-64-3] Dorsomorphin (Compound C)

Name: Dorsomorphin (Compound C)
Brand: Arctom Scientific
SKU: SLK-S7840

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PRODUCTS SPECIFICATIONS [866405-64-3]

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Catalog

SLK-S7840

Brand

Selleck

CAS

866405-64-3

DESCRIPTION [866405-64-3]

Overview

MDL	MFCD08705402
Molecular Weight	399.49
Molecular Formula	C24H25N5O
SMILES	O(CCN1CCCCC1)C2=CC=C(C3=CN4C(=C(C=N4)C=5C=CN=CC5)N=C3)C=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.5032 mL	12.5160 mL	25.0319 mL
5 mM	-	-	-
10 mM	-	-	-
50 mM	-	-	-

Description

Dorsomorphin (Compound C, BML-275) is a potent, reversible, selective inhibitor with of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin selectively inhibits the . Dorsomorphin is used in promoting specific cell differentiation and inducing cancer cell line autophagy. For animal testing, the water-soluble is recommended.

Targets

ALK2 ^[3]	ALK3 ^[3]	ALK6 ^[3]	AMPK ^[1] (Cell-free assay)
			109 nM(Ki)

In vitro

Dorsomorphin inhibits ACC inactivation by either AICAR or metformin, and also attenuates AICAR and metformin’s effect to increase fatty acid oxidation or suppress lipogenic genes in hepatocytes. Inhibition of AMPK activity by Dorsomorphin almost completely inhibits autophagic proteolysis in HT-29 cells. In addition, Dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6, and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation.

References

[1] Zhou G, et al. J Clin Invest. 2001, 108(8), 1167-1174.
[2] Meley D, et al. J Biol Chem. 2006, 281(46), 34870-34879.
[3] Yu PB, et al. Nat Chem Biol. 2008, 4(1), 33-41.
[4] Kim YM, et al. Atherosclerosis. 2011, 219(1), 57-64.

Synonyms

Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-

6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine

Dorsomorphin

Compound C

6-[4-(2-Piperidine-1-ylethoxy)phenyl]-3-pyridine-4-ylpyrazolo[1,5-a]pyrimidine