[CAS NO. 250612-42-1] Cyclo(RGDyK)
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PRODUCTS SPECIFICATIONS [250612-42-1]
Store
Catalog
SLK-S7844
Brand
Selleck
CAS
250612-42-1
DESCRIPTION [250612-42-1]
Overview
| MDL | MFCD20134101 |
|---|---|
| Molecular Weight | 847.72 |
| Molecular Formula | C31H43F6N9O12 |
| SMILES | O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C[C@@H](C(N[C@H](CC1=CC=C(O)C=C1)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(NC2)=O)=O)=O)=O)NC2=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.1796 mL | 5.8982 mL | 11.7963 mL |
| 5 mM | 0.2359 mL | 1.1796 mL | 2.3593 mL |
| 10 mM | 0.1180 mL | 0.5898 mL | 1.1796 mL |
| 50 mM | 0.0236 mL | 0.1180 mL | 0.2359 mL |
Description
Cyclo(RGDyK) is a potent and selective inhibitor with of 20 nM.
Targets
| αVβ3 integrin [1] |
| 20 nM |
In vitro
Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM).
In vivo
In apoE−/− mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery.
References
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