[CAS NO. 709002-46-0] SirReal2
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PRODUCTS SPECIFICATIONS [709002-46-0]
Store
Catalog
SLK-S7845
Brand
Selleck
CAS
709002-46-0
DESCRIPTION [709002-46-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 420.55 |
| Molecular Formula | C22H20N4OS2 |
| SMILES | O=C(NC1=NC=C(CC2=C3C=CC=CC3=CC=C2)S1)CSC4=NC(C)=CC(C)=N4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3778 mL | 11.8892 mL | 23.7784 mL |
| 5 mM | 0.4756 mL | 2.3778 mL | 4.7557 mL |
| 10 mM | 0.2378 mL | 1.1889 mL | 2.3778 mL |
| 50 mM | 0.0476 mL | 0.2378 mL | 0.4756 mL |
Description
SirReal2 is a potent and selective inhibitor with of 140 nM.
Targets
| SIRT2 [1] (Cell-free assay) |
| 140 nM |
In vitro
SirReal2 selectively inhibits Sirt2 via a Sirt2-specific amino acid network, and induces a tubulin hyperacetylation and a significant depletion of BubR1 in HeLa cells.
In vivo
In vivo, SirReal2 inhibits Sirt2 activity without affecting the activity of the other Class-I sirtuins Sirt1 and Sirt3.
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