[CAS NO. 5369-03-9]  QX-314 chloride

As a sodium channel blocker, QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in a concentration-dependent manner. QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca²⁺ currents are on average <45% of control amplitude.^{[1] [2]}