[CAS NO. 491833-29-5] Eliglustat

Name: Eliglustat
Brand: Arctom Scientific
SKU: SLK-S7852

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PRODUCTS SPECIFICATIONS [491833-29-5]

Store

Catalog

SLK-S7852

Brand

Selleck

CAS

491833-29-5

DESCRIPTION [491833-29-5]

Overview

MDL	MFCD19443735
Molecular Weight	404.54
Molecular Formula	C23H36N2O4
SMILES	[C@@H]([C@@H](CN1CCCC1)NC(CCCCCCC)=O)(O)C=2C=C3C(=CC2)OCCO3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Eliglustat (GENZ-112638) inhibits (IC50=20 nM in intact MDCK cells), thus reducing the load of glucosylceramide influx into the lysosome.

Targets

glucosylceramide synthase ^[1]
(In intact MDCK cells)

20 nM

In vitro

Eliglustat tartrate is designed and developed to inhibit glucosylceramide synthase, the enzyme that catalyzes the formation of glucosylceramide from UDP-glucose and ceramide.The inhibition of glucosylceramide synthase by eliglustat tartrate is highly specific. Eliglustat tartrate displays limited or no activity against a variety of glycosidases. Additionally, no inhibition of sucrase or maltase is observed at drug concentrations up to 10 μM.

In vivo

Preclinical studies in normal mice, rats and dogs with i.v. and oral administration demonstrates significant dose-related decreases in spleen, kidney and liver glucosylceramide content, consistent with prior observations with the palmitoyl homologue.In rodents, Genz-112638 is rapidly metabolized with a half-life of 15–45 minutes.

References

[1] Shayman JA. Drugs Future. 2010, 35(8):613-620.
[2] Nelson S. Yew, et al. PLoS One. 2010, 5(6):e11239.

Synonyms

Octanamide, N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-

N-[(1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]octanamide

Eliglustat

Genz 99067

Cerdelga