[CAS NO. 869886-67-9] Ulixertinib (BVD-523)
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PRODUCTS SPECIFICATIONS [869886-67-9]
Store
Catalog
SLK-S7854
Brand
Selleck
CAS
869886-67-9
DESCRIPTION [869886-67-9]
Overview
| MDL | MFCD22628898 |
|---|---|
| Molecular Weight | 433.33 |
| Molecular Formula | C21H22Cl2N4O2 |
| SMILES | O=C(C1=CC(C2=CC(NC(C)C)=NC=C2Cl)=CN1)N[C@@H](C3=CC=CC(Cl)=C3)CO |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3077 mL | 11.5386 mL | 23.0771 mL |
| 5 mM | 0.4615 mL | 2.3077 mL | 4.6154 mL |
| 10 mM | 0.2308 mL | 1.1539 mL | 2.3077 mL |
| 50 mM | 0.0462 mL | 0.2308 mL | 0.4615 mL |
Description
Ulixertinib (BVD-523, VRT752271) is a potent and reversible inhibitor with of <0.3 nM for ERK2. Phase 1.
In vitro
In an A375 melanoma cell line containing a b-RAFV600E mutation, Ulixertinib reduces the levels of phosphorylated ERK2 (pERK) and of the phosphorylation of the downstream kinase RSK (pRSK) with IC50 of 4.1/0.14 μM, respectively. Ulixertinib also inhibits A375 cell proliferation with IC50 of 180 nM.
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