[CAS NO. 16980-89-5] Dibutyryl-cAMP (Bucladesine)

Name: Dibutyryl-cAMP (Bucladesine)
Brand: Arctom Scientific
SKU: SLK-S7858

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PRODUCTS SPECIFICATIONS [16980-89-5]

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Catalog

SLK-S7858

Brand

Selleck

CAS

16980-89-5

DESCRIPTION [16980-89-5]

Overview

MDL	MFCD00005843
Molecular Weight	491.37
Molecular Formula	C18H23N5NaO8P
SMILES	O(C(CCC)=O)[C@H]1[C@@](O[C@]2([C@]1(OP(=O)(O)OC2)[H])[H])(N3C=4C(N=C3)=C(NC(CCC)=O)N=CN4)[H].[Na]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.0351 mL	10.1756 mL	20.3513 mL
5 mM	0.4070 mL	2.0351 mL	4.0703 mL
10 mM	0.2035 mL	1.0176 mL	2.0351 mL
50 mM	0.0407 mL	0.2035 mL	0.4070 mL

Description

Dibutyryl-cAMP (Bucladesine, dbcAMP) is a cell-permeable activator by mimicing the action of endogenous cAMP. Dibutyryl-cAMP (Bucladesine) is also a inhibitor.

Targets

PDE ^[5]

PKA ^[1]

In vitro

Dibutyryl-cAMP inhibits neuronal glucose uptake via PKA activation. In cultured rat hepatocytes, Dibutyryl-cAMP inhibits inducible nitric oxide synthase expression and NF-kappaB-binding activity. Dibutyryl-cAMP also suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation.

References

[1] Prapong T, et al. Exp Neurol. 2001, 167(1), 59-64.
[2] Harbrecht BG, et al. J Surg Res. 2001, 99(2), 258-264.
[3] Wang Y, et al. Apoptosis. 2006, 11(3), 441-451.
[4] Biol Trace Elem Res. 2015, DOI10.1007/s12011-015-0399-z
[5] Chris Rundfeldt, et al. Arch Dermatol Res . 2012 May;304(4):313-7.
[6] Shimojo M, et al. J Neurochem. 1998 Sep;71(3):1118-26.

Synonyms

Adenosine, N-(1-oxobutyl)-, cyclic 3′,5′-(hydrogen phosphate) 2′-butanoate, sodium salt (1:1)

Butyramide, N-(9-β-D-ribofuranosyl-9H-purin-6-yl)-, cyclic hydrogen phosphate butyrate (ester), monosodium salt

Adenosine, N-(1-oxobutyl)-, cyclic 3′,5′-(hydrogen phosphate) 2′-butanoate, monosodium salt

4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, adenosine deriv.

N-6,O-2′-Dibutyryladenosine cyclic 3′,5′-monophosphate sodium salt

Dibutyryl cyclic AMP monosodium salt

N⁶,2′-O-Dibutyryl-3′,5′-cyclic AMP sodium salt

Sodium dibutyryl 3′,5′-cyclic AMP

Dibutyryl cyclic AMP sodium salt

Dibutyryl cyclic AMP sodium

N⁶,2′-O-Dibutyryladenosine-3′,5′-monophosphate monosodium salt

Monosodium dibutyryl cyclic AMP

Dibutyryl 3′,5′-cyclic AMP sodium salt

N⁶,O²′-Dibutyryl-3′,5′-cyclic AMP sodium salt

Sodium dibutyryl cAMP

Dibutyryl-cAMP sodium salt

Bucladesine sodium

Sodium N⁶,2′-O-dibutyryladenosine 3′,5′-cyclic phosphate

Bucladesine sodium salt

DC 2797