[CAS NO. 82-08-6] Rottlerin

Name: Rottlerin
Brand: Arctom Scientific
SKU: SLK-S7862

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PRODUCTS SPECIFICATIONS [82-08-6]

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Catalog

SLK-S7862

Brand

Selleck

CAS

82-08-6

DESCRIPTION [82-08-6]

Overview

MDL	MFCD00017361
Molecular Weight	516.54
Molecular Formula	C30H28O8
SMILES	C(/C=C/C1=CC=CC=C1)(=O)C2=C3C(=C(O)C(CC4=C(O)C(C(C)=O)=C(O)C(C)=C4O)=C2O)C=CC(C)(C)O3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9360 mL	9.6798 mL	19.3596 mL
5 mM	0.3872 mL	1.9360 mL	3.8719 mL
10 mM	0.1936 mL	0.9680 mL	1.9360 mL
50 mM	-	-	-

Description

Rottlerin (Mallotoxin, NSC 56346, NSC 94525), a natural compound purified from Mallotus Philippinensis, is a specific inhibitor with IC50 of 3 μM, 6 μM and 5.3 μM for PKCδ(from baculovirus-infected Sf9 insect cells), PKCδ(from porcine spleen) and CaM kinase III, respectively. Rottlerin also inhibits PKCα, PKCγ, PKCβ, PKCη, CKII and PKA with IC50 of 30 μM, 40 μM, 42 μM, 82 μM, 30 μM and 78 μM, respectively.

Targets

In vitro

Rottlerin is extracted from the plasma and tissues using protein precipitation-extraction and analyzed by reverse-phase HPLC-DAD method. Significant levels of rottlerin are detected in cell lysates from rottlerin-treated HPAF-II cells. These data indicate that rottlerin is efficiently absorbed in cells in vitro.

References

[1] M Gschwendt, et al. Biochem Biophys Res Commun. 1994 Feb 28;199(1):93-8.
[2] Qing-Yi Lu, et al. J Chromatogr Sep Tech. 2013 Jan 1;4(1):100062.

Synonyms

2-Propen-1-one, 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-, (2E)-

Rottlerin

Acetophenone, 3′-[(8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2′,4′,6′-trihydroxy-5′-methyl-

2-Propen-1-one, 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-, (E)-

(2E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one

NSC 56346

NSC 94525

Mallotoxin

PKC-δ/PKC-θ inhibitor