[CAS NO. 64224-21-1] Oltipraz

Name: Oltipraz
Brand: Arctom Scientific
SKU: SLK-S7864

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [64224-21-1]

Store

Catalog

SLK-S7864

Brand

Selleck

CAS

64224-21-1

DESCRIPTION [64224-21-1]

Overview

MDL	MFCD00868499
Molecular Weight	226.34
Molecular Formula	C8H6N2S3
SMILES	CC1=C(SSC1=S)C=2C=NC=CN2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.4181 mL	22.0907 mL	44.1813 mL
5 mM	0.8836 mL	4.4181 mL	8.8363 mL
10 mM	0.4418 mL	2.2091 mL	4.4181 mL
50 mM	0.0884 mL	0.4418 mL	0.8836 mL

Description

Oltipraz is a potent activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.

Targets

Nrf2 ^[1]

In vitro

Oltipraz, as a chemoprotective agent, induces Phase II detoxification enzyme activity in a Nrf2-dependent manner. In human HT29 colon cancer cells, oltipraz inhibits the induction of HIF-1α by insulin, hypoxia or CoCl2 by significantly accelerating degradation of HIF-1α protein.

In vivo

Oltipraz (500 mg/kg, p.o.) significantly reduces multiplicity of gastric neoplasia in wild-type mice by 55%, but has no effect on tumor burden in nrf2-deficient mice. In BALB/c nude mice transplanted with HCT116 cells, Oltipraz (200 mg/kg, p.o.) inhibits tumor growth and angiogenesis via inhibition of HIF-1α. In rats on a CDAA diet, Oltipraz attenuate the progression of nonalcoholic steatohepatitis-related fibrosis.

References

[1] Ramos-Gomez M, et al. Proc Natl Acad Sci U S A. 2001, 98(6), 3410-3415..
[2] Lee WH, et al. Mol Cancer Ther. 2009, 8(10), 2791-2802.
[3] Shimozono R, et al. Mol Pharmacol. 2013, 84(1), 62-70.

Synonyms

3H-1,2-Dithiole-3-thione, 4-methyl-5-(2-pyrazinyl)-

3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-

4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione

RP 35972

Oltipraz

NSC 347901

4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione