[CAS NO. 1627710-50-2] LJH685
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PRODUCTS SPECIFICATIONS [1627710-50-2]
Store
Catalog
SLK-S7870
Brand
Selleck
CAS
1627710-50-2
DESCRIPTION [1627710-50-2]
Overview
| MDL | MFCD29924738 |
|---|---|
| Molecular Weight | 381.42 |
| Molecular Formula | C22H21F2N3O |
| SMILES | OC1=C(F)C=C(C2=C(C3=CC=C(N4CCN(C)CC4)C=C3)C=CN=C2)C=C1F |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6218 mL | 13.1089 mL | 26.2178 mL |
| 5 mM | 0.5244 mL | 2.6218 mL | 5.2436 mL |
| 10 mM | 0.2622 mL | 1.3109 mL | 2.6218 mL |
| 50 mM | 0.0524 mL | 0.2622 mL | 0.5244 mL |
Description
LJH685 is a potent pan- inhibitor with of 6 nM, 5 nM and 4 nM for RSK1, RSK2, and RSK3, respectively.
In vitro
LJH685 modulates YB1 phosphorylation by potently and selectively inhibiting RSK in cells. In MAPK pathway–dependent cancer cell lines, LJH685 shows antiproliferative effects, and causes cell-cycle regulation and apoptosis induction.
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