[CAS NO. 1351635-67-0] ONO-4059 analogue
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PRODUCTS SPECIFICATIONS [1351635-67-0]
Store
Catalog
SLK-S7877
Brand
Selleck
CAS
1351635-67-0
DESCRIPTION [1351635-67-0]
Overview
| MDL | MFCD29049511 |
|---|---|
| Molecular Weight | 456.50 |
| Molecular Formula | C25H24N6O3 |
| SMILES | O=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[C@@H]5CN(C(C=C)=O)CCC5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1906 mL | 10.9529 mL | 21.9058 mL |
| 5 mM | 0.4381 mL | 2.1906 mL | 4.3812 mL |
| 10 mM | 0.2191 mL | 1.0953 mL | 2.1906 mL |
| 50 mM | - | - | - |
Description
ONO-4059 analogue (ONO-WG-307) is an analogue of ONO-4059, which is a highly potent and selective oral inhibitor with of 23.9 nM. Phase 1.
Targets
| BTK [1] |
| 23.9 nM |
In vitro
In TMD-8 cells, ONO-4059 inhibits cell growth with IC50 of 3.59 nM, and induces cell apoptosis. The combination of of ONO-4059 with doxorubicin, etoposide, vincristine or dexamethasone causes the increased apoptosis ratio.
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