[CAS NO. 1884220-36-3] SBI-0206965
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PRODUCTS SPECIFICATIONS [1884220-36-3]
Store
Catalog
SLK-S7885
Brand
Selleck
CAS
1884220-36-3
DESCRIPTION [1884220-36-3]
Overview
| MDL | MFCD29472244 |
|---|---|
| Molecular Weight | 489.32 |
| Molecular Formula | C21H21BrN4O5 |
| SMILES | O=C(NC)C1=CC=CC=C1OC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Br |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0437 mL | 10.2183 mL | 20.4365 mL |
| 5 mM | 0.4087 mL | 2.0437 mL | 4.0873 mL |
| 10 mM | 0.2044 mL | 1.0218 mL | 2.0437 mL |
| 50 mM | 0.0409 mL | 0.2044 mL | 0.4087 mL |
Description
SBI-0206965 is a highly selective autophagy kinase inhibitor with of 108 nM, about 7-fold selectivity over ULK2. SBI-0206965 inhibits and enhances in human glioblastoma and lung cancer cells.
In vitro
In HEK293T transfected with WT or KI Myc-tagged ULK1 and WT Vps34, SBI-0206965 inhibits Ser249 phosphorylation of overexpressed Vps34 and Beclin1 Ser15 phosphorylation. SBI-0206965 suppresses autophagy induced by mTOR inhibition in A549 cells, and prevents ULK1-dependent cell survival in WT MEFs. In addition, SBI-0206965 also synergizes with mTOR inhibition to induce cancer cell death.
References
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