[CAS NO. 1441190-66-4] 2',3'-cGAMP Sodium Salt
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PRODUCTS SPECIFICATIONS [1441190-66-4]
Store
Catalog
SLK-S7904
Brand
Selleck
CAS
1441190-66-4
DESCRIPTION [1441190-66-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 718.37 |
| Molecular Formula | C20H22N10Na2O13P2 |
| SMILES | O[C@H]1[C@@]2([C@@](O[C@@]1(COP(=O)(O)O[C@@]3([C@@](COP(=O)(O)O2)(O[C@]([C@@H]3O)(N4C=5C(N=C4)=C(N)N=CN5)[H])[H])[H])[H])(N6C7=C(N=C6)C(=O)N=C(N)N7)[H])[H] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds with high affinity and is an effective inducer of . 2',3'-cGAMP binds to with Kd of 3.79 nM.
Targets
| STING [1] (Cell-free assay) |
| 3.79 nM(Kd) |
In vitro
2',3'-cGAMP is an endogenous second messenger produced by mammalian cells. 2',3'-cGAMP is a high affinity ligand for STING. 2',3'-cGAMP is a potent inducer of type-I interferons. 2',3'-cGAMP binding induces conformational changes of STING.
References
Synonyms
2′-Guanylic acid, adenylyl-(3′→5′)-, cyclic nucleotide
2′-3′-cyclic GMP-AMP
Cyclic Gp(2′→5′)Ap(3′→5′)
cGAMP(2′→5′)
2′,3′-Cyclic guanosine monophosphate-adenosine monophosphate
2′,3′-Cyclic guanosine adenosine monophosphate
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