[CAS NO. 1204669-58-8] Epacadostat (INCB024360)
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PRODUCTS SPECIFICATIONS [1204669-58-8]
Store
Catalog
SLK-S7910
Brand
Selleck
CAS
1204669-58-8
DESCRIPTION [1204669-58-8]
Overview
| MDL | MFCD26142934 |
|---|---|
| Molecular Weight | 438.23 |
| Molecular Formula | C11H13BrFN7O4S |
| SMILES | C(\NC1=CC(Br)=C(F)C=C1)(=N\O)/C=2C(NCCNS(N)(=O)=O)=NON2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2819 mL | 11.4095 mL | 22.8191 mL |
| 5 mM | 0.4564 mL | 2.2819 mL | 4.5638 mL |
| 10 mM | 0.2282 mL | 1.1410 mL | 2.2819 mL |
| 50 mM | 0.0456 mL | 0.2282 mL | 0.4564 mL |
Description
Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO).
Targets
| IDO1 [1] (immune cells) |
| 10 nM |
In vitro
In IFN-γ–treated human HeLa cells, INCB024360 potently inhibits kynurenine production. INCB024360 also promotes T and natural killer (NK)-cell growth, increases IFN-gamma production, and reduces conversion to regulatory T (T(reg))-like cells.
References
Synonyms
1,2,5-Oxadiazole-3-carboximidamide, 4-[[2-[(aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-, [C(Z)]-
[C(Z)]-4-[[2-[(Aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide
INCB 024360
Epacadostat
ICBN 24360
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