[CAS NO. 667463-85-6] BIO-acetoxime
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PRODUCTS SPECIFICATIONS [667463-85-6]
Store
Catalog
SLK-S7915
Brand
Selleck
CAS
667463-85-6
DESCRIPTION [667463-85-6]
Overview
| MDL | MFCD09037533 |
|---|---|
| Molecular Weight | 398.21 |
| Molecular Formula | C18H12BrN3O3 |
| SMILES | O=C1NC2=C(C=CC(Br)=C2)/C1=C3NC4=C(C=CC=C4)C/3=N\OC(C)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5112 mL | 12.5562 mL | 25.1124 mL |
| 5 mM | 0.5022 mL | 2.5112 mL | 5.0225 mL |
| 10 mM | 0.2511 mL | 1.2556 mL | 2.5112 mL |
| 50 mM | 0.0502 mL | 0.2511 mL | 0.5022 mL |
Description
BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual inhibitor with of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.
In vitro
In human oral epithelial cells, BIO-acetoxime suppresses viral gene expression and protects oral epithelial cells from HSV-1 infection. In SY5Y-MYCN cells, BIO-acetoxime strongly reduces c-MYC expression and p-SMAD3 levels. BIO-acetoxime also decreases cell viability of KCN, KCNR, SY5Y, Kelly, and IMR32 cells by mediating apoptosis. In HEK 293T cells, BIO-acetoxime is also found to reduce antiviral innate immunity downstream of IRF3 activation by inhibition of GSK3α/β activities.
References
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