[CAS NO. 1203494-49-8] DASA-58
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PRODUCTS SPECIFICATIONS [1203494-49-8]
Store
Catalog
SLK-S7928
Brand
Selleck
CAS
1203494-49-8
DESCRIPTION [1203494-49-8]
Overview
| MDL | MFCD29472280 |
|---|---|
| Molecular Weight | 453.53 |
| Molecular Formula | C19H23N3O6S2 |
| SMILES | NC1=CC=CC(S(=O)(N2CCN(S(=O)(C3=CC=C(OCCO4)C4=C3)=O)CCC2)=O)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2049 mL | 11.0246 mL | 22.0493 mL |
| 5 mM | 0.4410 mL | 2.2049 mL | 4.4099 mL |
| 10 mM | 0.2205 mL | 1.1025 mL | 2.2049 mL |
| 50 mM | 0.0441 mL | 0.2205 mL | 0.4410 mL |
Description
DASA-58 is a specific and potent activator.
Targets
| PKM2 [1] |
In vitro
DASA-58 inhibits LPS-induced Hif-1α and IL-1β, as well as the expression of a range of other Hif-1α-dependent genes in primary BMDMs, and also inhibits glycolysis and the accumulation of succinate in LPS-activated macrophages. In PC3 cells, DASA-58 impairs stromal-induced EMT program by restoring PK activity and abrogating the nuclear translocation of PKM2, as well as its association with HIF-1α. DASA-58 also dramatically reduces (~6-fold) CAFs-induced lung metastases formation in PC3 cells.
In vivo
DASA-58 (40 μM) affects EMT of prostate cancers and tumor dissemination in SCID mice.
References
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