[CAS NO. 259793-96-9] Favipiravir (T-705)

Name: Favipiravir (T-705)
Brand: Arctom Scientific
SKU: SLK-S7975

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PRODUCTS SPECIFICATIONS [259793-96-9]

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Catalog

SLK-S7975

Brand

Selleck

CAS

259793-96-9

DESCRIPTION [259793-96-9]

Overview

MDL	-
Molecular Weight	157.1
Molecular Formula	C5H4FN3O2
SMILES	C(N)(=O)C=1C(=O)NC=C(F)N1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	6.3654 mL	31.8269 mL	63.6537 mL
5 mM	1.2731 mL	6.3654 mL	12.7307 mL
10 mM	0.6365 mL	3.1827 mL	6.3654 mL
50 mM	0.1273 mL	0.6365 mL	1.2731 mL

Description

Favipiravir (T-705) is a potent and selective inhibitor, used to treat influenza virus infections.

Targets

RNA-dependent RNA polymerase ^[1]

In vitro

Favipiravir shows anti-influenza virus activities with IC50 ranged from 0.013 to 0.48 μg/ml for the influenza A viruses, from 0.039 to 0.089 μg/ml for the influenza B viruses, and from 0.030 to 0.057 μg/ml for the influenza C viruses. In mammalian cell lines (MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells), Favipiravir shows no cytotoxicity at concentrations up to 1,000 μg/ml. In MDCK cells inoculated with seasonal influenza A (H1N1) viruses, Favipiravir induces lethal mutagenesis.

In vivo

In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively.

References

[1] Furuta Y, et al. Antimicrob Agents Chemother. 2002, 46(4), 977-981.
[2] Baranovich T, et al. J Virol. 2013, 87(7), 3741-3751.
[3] Madelain V, et al. Antiviral Res. 2015, 123, 70-77.

Synonyms

2-Pyrazinecarboxamide, 6-fluoro-3,4-dihydro-3-oxo-

Pyrazinecarboxamide, 6-fluoro-3,4-dihydro-3-oxo-

6-Fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide

6-Fluoro-3-hydroxy-2-pyrazinecarboxamide

T 705

T 705 (pharmaceutical)

Favipiravir

Avigan

Favilavir

FabiFlu