[CAS NO. 83280-65-3] Napabucasin (BBI608)
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PRODUCTS SPECIFICATIONS [83280-65-3]
Store
Catalog
SLK-S7977
Brand
Selleck
CAS
83280-65-3
DESCRIPTION [83280-65-3]
Overview
| MDL | MFCD28155270 |
|---|---|
| Molecular Weight | 240.21 |
| Molecular Formula | C14H8O4 |
| SMILES | O=C(C1=C2OC(C(C)=O)=C1)C3=C(C2=O)C=CC=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.1630 mL | 20.8151 mL | 41.6302 mL |
| 5 mM | 0.8326 mL | 4.1630 mL | 8.3260 mL |
| 10 mM | 0.4163 mL | 2.0815 mL | 4.1630 mL |
| 50 mM | 0.0833 mL | 0.4163 mL | 0.8326 mL |
Description
Napabucasin (BBI608) is an orally available and cancer cell stemness inhibitor.
Targets
| Stat3 [1] |
In vitro
Napabucasin downregulates stemness gene expression driven by Stat3 and cancer stemness properties, and effectively inhibits self-renewal of stemness-high cancer cells with IC50 ranged from 0.291~1.19 μM, on inhibition on normal stem cells.
In vivo
In mice bearing PaCa-2 xenografts, Napabucasin (20 mg/kg, i.p.) significantly inhibits tumor growth, relapse and metastasis.
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