[CAS NO. 1383716-33-3] VPS34-IN1
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PRODUCTS SPECIFICATIONS [1383716-33-3]
Store
Catalog
SLK-S7980
Brand
Selleck
CAS
1383716-33-3
DESCRIPTION [1383716-33-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 425.91 |
| Molecular Formula | C21H24ClN7O |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3479 mL | 11.7396 mL | 23.4791 mL |
| 5 mM | 0.4696 mL | 2.3479 mL | 4.6958 mL |
| 10 mM | 0.2348 mL | 1.1740 mL | 2.3479 mL |
| 50 mM | 0.0470 mL | 0.2348 mL | 0.4696 mL |
Description
Vps34-IN1 is a potent and highly selective inhibitor with of 25 nM invitro,which does not significantly inhibit the isoforms of class I as well as class II PI3Ks. Vps34-IN1 modulates .
Targets
| Vps34 [1] (Cell-free assay) |
| 25 nM |
In vitro
Administration of VPS34-IN1 to cells induces a rapid dose-dependent dispersal of a specific PtdIns(3)P-binding probe from endosome membranes, within 1min, without affecting the ability of class I PI3K to regulate Akt. It can also induce a rapid ~50-60% loss of SGK3 phosphorylation within 1min. VPS34-IN1 has no inhibition to the SGK2 isoform that does not possess a PtdIns(3)P-binding PX domain.
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