[CAS NO. 62717-42-4] SKF38393 HCl

Name: SKF38393 HCl
Brand: Arctom Scientific
SKU: SLK-S7993

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PRODUCTS SPECIFICATIONS [62717-42-4]

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Catalog

SLK-S7993

Brand

Selleck

CAS

62717-42-4

DESCRIPTION [62717-42-4]

Overview

MDL	MFCD00069248
Molecular Weight	291.77
Molecular Formula	C16H17NO2 . HCl
SMILES	OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.4274 mL	17.1368 mL	34.2736 mL
5 mM	0.6855 mL	3.4274 mL	6.8547 mL
10 mM	0.3427 mL	1.7137 mL	3.4274 mL
50 mM	0.0685 mL	0.3427 mL	0.6855 mL

Description

SKF38393 HCl is a selective agonist.

Targets

dopamine D1 receptor ^[1]

D5 receptor ^[1]

In vitro

SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations.

In vivo

SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning.

References

[1] Huang YY, et al. Proc Natl Acad Sci U S A. 1995, 92(7), 2446-2450.
[2] Gorelova NA, et al. J Neurophysiol. 2000, 84(1), 75-87.
[3] Amico F, et al. Eur J Pharmacol. 2007, 577(1-3), 71-77.
[4] Reichenbach N, et al. Proteome Sci. 2015, 13, 13.
[5] Nasehi M, et al. Psychopharmacology (Berl). 2016, 233(2), 213-224.