[CAS NO. 130495-35-1] SKF96365

Name: SKF96365
Brand: Arctom Scientific
SKU: SLK-S7999

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PRODUCTS SPECIFICATIONS [130495-35-1]

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Catalog

SLK-S7999

Brand

Selleck

CAS

130495-35-1

DESCRIPTION [130495-35-1]

Overview

MDL	MFCD00236407
Molecular Weight	402.91
Molecular Formula	C22H26N2O3.HCl
SMILES	C(CN1C=CN=C1)(OCCCC2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4819 mL	12.4097 mL	24.8194 mL
5 mM	0.4964 mL	2.4819 mL	4.9639 mL
10 mM	0.2482 mL	1.2410 mL	2.4819 mL
50 mM	0.0496 mL	0.2482 mL	0.4964 mL

Description

SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of .

Targets

TRPC ^[1]

In vitro

SKF-96365 exhibits protective activity against MPP+ injury in PC12 cells and significantly inhibits apoptotic cell death in PC12 cells after MPP+ administration. SKF-96365 does not exert effects on necrotic cell death induced by MPP+ insult in PC12 cells. Because of its non-selective activity, SKF-96365 has been demonstrated to have effects on multiple other Ca2+ channels: it not only blocks high-voltage-activated (HVA) Ca2+ channels at typically utilized test concentrations, but also potently inhibits low-voltage -activated (LVA) T-type Ca2+ channels in HEK293 cells. The exact effect of SKF-96365 on intracellular calcium homeostasis might dependent on cell types and experimental models used.

In vivo

SKF-96365 treatment inhibited the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade in vitro and in vivo.

References

[1] Singh A, et al. Br J Pharmacol. 2010, 160(6):1464-1475.
[2] Chen T, et al. PLoS One. 2013, 8(1):e55601.
[3] Yao H, et al. Cell Death Differ. 2009, 16(12):1681-1693.
[4] Jing Z, et al. Cancer Lett. 2016, 372(2):226-38.

Synonyms

1H-Imidazole, 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-, hydrochloride (1:1)

1H-Imidazole, 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-, monohydrochloride

SKF 96365

1-(2-(4-Methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)-1H-imidazole hydrochloride