[CAS NO. 196868-63-0] PQ 401
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [196868-63-0]
Store
Catalog
SLK-S8003
Brand
Selleck
CAS
196868-63-0
DESCRIPTION [196868-63-0]
Overview
| MDL | MFCD00160558 |
|---|---|
| Molecular Weight | 341.79 |
| Molecular Formula | C18H16ClN3O2 |
| SMILES | O=C(NC1=CC(C)=NC2=CC=CC=C12)NC3=CC(Cl)=CC=C3OC |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
PQ401 inhibits autophosphorylation of domain with of <1 μM.
Targets
| IGF-1R [1] |
| <1 μM |
In vitro
PQ 401 is an IGF-1R inhibitor and inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1μM. PQ 401 significantly reduced proliferation of MCF-7 cells with IC50 of 8 μM. PQ 401 also inhibits growth of MCNeuA cells with IC50 of 15 μM. PQ 401 inhibits the IGF-I-mediated antiapoptotic pathway in MCF-7 cells. PQ 401 increases caspase-mediated apoptotic activity in MCF-7 cells.
In vivo
PQ 401 (50 mg/Kg, 100 mg/Kg) significantly inhibits MCNeuA tumor growth in a dose-dependent manner.
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.