[CAS NO. 1232410-49-9] VE-821
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PRODUCTS SPECIFICATIONS [1232410-49-9]
Store
Catalog
SLK-S8007
Brand
Selleck
CAS
1232410-49-9
DESCRIPTION [1232410-49-9]
Overview
| MDL | MFCD19443686 |
|---|---|
| Molecular Weight | 368.41 |
| Molecular Formula | C18H16N4O3S |
| SMILES | O=C(C1=NC(C2=CC=C(S(=O)(C)=O)C=C2)=CN=C1N)NC3=CC=CC=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
VE-821 is a potent and selective ATP competitive inhibitor of with / of 13 nM/26 nM in cell-free assays, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ.
Targets
| ATR [1] (Cell-free assay) |
| 13 nM(Ki) |
In vitro
VE-821 shows excellent selectivity for ATR with minimal cross-reactivity against the related PIKKs ATM, DNA-PK, mTOR and PI3K (Ks of 16 μM, 2.2 μM, >1 μM and 3.9 μM, respectively. VE-821 alone commits a large fraction of cancer cell populations to death, but it only reversibly limits cell cycle progression in normal cells, with minimal death or long-term detrimental effects. VE-821 along with cisplatin treatment shows the most marked synergy. VE-821 inhibits H2AX cell growth with IC50 of 800 nM.
References
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