[CAS NO. 50892-23-4] WY-14643 (Pirinixic Acid)

Name: WY-14643 (Pirinixic Acid)
Brand: Arctom Scientific
SKU: SLK-S8029

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PRODUCTS SPECIFICATIONS [50892-23-4]

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Catalog

SLK-S8029

Brand

Selleck

CAS

50892-23-4

DESCRIPTION [50892-23-4]

Overview

MDL	MFCD00191335
Molecular Weight	323.8
Molecular Formula	C14H14ClN3O2S
SMILES	N(C1=NC(SCC(O)=O)=NC(Cl)=C1)C2=C(C)C(C)=CC=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.0883 mL	15.4416 mL	30.8833 mL
5 mM	0.6177 mL	3.0883 mL	6.1767 mL
10 mM	0.3088 mL	1.5442 mL	3.0883 mL
50 mM	0.0618 mL	0.3088 mL	0.6177 mL

Description

WY-14643 (Pirinixic Acid, NSC 310038) is a potent and selective activator with an EC50 of 1.5 μM.

Targets

PPARα ^[1]

1.5 μM(EC50)

In vitro

WY 14643 (10 μM) almost completely inhibits interleukin-1-induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2 in aortic smooth-muscle cells, through repression of NF-κB signaling. WY14643 (250 μM) reduces VCAM-1 expression levels significantly, to 52 % of TNF-α-stimulated human endothelial cells. Pretreatment of endothelial cells with WY 14643 (10 μM) before TNF-α stimulation reduces U937 cell adhesion by 50%.

References

[1] Issemann I, et al. Nature. 1990, 347(6294), 645-650.
[2] Staels B, et al. Nature. 1998, 393(6687), 790-793.
[3] Marx N, et al. Circulation, 1999, 99(24), 3125-3131.
[4] Wayman NS, et al. FASEB J. 2002, 16(9), 1027-1040.
[5] Ye JM, et al. Diabetes, 2001, 50(2), 411-417.

Synonyms

Acetic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-

Acetic acid, [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-

2-[[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid

Wy 14643

[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid

Pirinixic acid

Pirnixic acid

NSC 310038

2-[4-Chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanylacetic acid