[CAS NO. 164178-33-0] 6-Iodopravadoline (AM630)

Name: 6-Iodopravadoline (AM630)
Brand: Arctom Scientific
SKU: SLK-S8033

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PRODUCTS SPECIFICATIONS [164178-33-0]

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Catalog

SLK-S8033

Brand

Selleck

CAS

164178-33-0

DESCRIPTION [164178-33-0]

Overview

MDL	-
Molecular Weight	504.36
Molecular Formula	C23H25IN2O3
SMILES	C(=O)(C=1C=2C(N(CCN3CCOCC3)C1C)=CC(I)=CC2)C4=CC=C(OC)C=C4

For research use only.

Storage

2 years -80 in solvent
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9827 mL	9.9136 mL	19.8271 mL
5 mM	0.3965 mL	1.9827 mL	3.9654 mL
10 mM	0.1983 mL	0.9914 mL	1.9827 mL
50 mM	0.0397 mL	0.1983 mL	0.3965 mL

Description

6-Iodopravadoline (AM630) is a selective antagonist with Ki of 31.2 nM.

Targets

CB2 receptor ^[1]
(Cell-free assay)

31.2 nM(Ki)

In vitro

AM630 behaves as a low-potency neutral competitive antagonist in AM630-pre-incubated cells, a low-potency agonist in SR144528-pre-incubated cells, and a much higher-potency inverse agonist/antagonist in vehicle-pre-incubated cells. AM630 is a protean ligand that can target a constitutively active form of the hCB2 receptor with low affinity to produce agonism or neutral antagonism and a constitutively inactive form of this receptor with much higher affinity to produce inverse agonism.

References

[1] María S García-Gutiérrez, et al. Br J Pharmacol. 2012 Feb;165(4):951-64.
[2] Daniele Bolognini, et al. Br J Pharmacol. 2012 Apr;165(8):2561-74.

Synonyms

Methanone, [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)-

[6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone

AM 630

Iodopravadoline

[6-Iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone