[CAS NO. 4311-88-0] Necrostatin-1
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PRODUCTS SPECIFICATIONS [4311-88-0]
Store
Catalog
SLK-S8037
Brand
Selleck
CAS
4311-88-0
DESCRIPTION [4311-88-0]
Overview
| MDL | MFCD00056916 |
|---|---|
| Molecular Weight | 259.33 |
| Molecular Formula | C13H13N3OS |
| SMILES | CN1C(NC(CC2=CNC3=C2C=CC=C3)C1=O)=S |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.8561 mL | 19.2805 mL | 38.5609 mL |
| 5 mM | 0.7712 mL | 3.8561 mL | 7.7122 mL |
| 10 mM | 0.3856 mL | 1.9280 mL | 3.8561 mL |
| 50 mM | 0.0771 mL | 0.3856 mL | 0.7712 mL |
Description
Necrostatin-1 (Nec-1) is a specific inhibitor and inhibits TNF-α-induced necroptosis with of 490 nM in 293T cells. Necrostatin-1 also blocks and suppresses and .
Features
A powerful tool for characterizing the role of necroptosis with characterized primary target.
Targets
| RIP1 [1] (293T cells) |
| 490 nM(EC50) |
In vitro
Necrostatin-1 (1-100 μM) inhibits the autophosphorylation of overexpressed and endogenous RIP1.It is found RIP1 is the primary cellular target responsible for the antinecroptosis activity of Necrostatin-1. Necrostatin-1 efficiently suppresses necroptotic cell death triggered by an array of stimuli in a variety of cell types. Necrostatin-1, previously identified as small-molecule inhibitor of necroptosis, inhibits RIP kinase-induced necroptosis and inhibits TNF-α-induced necroptosis in jurkat cells with EC50 of 490 nM.
References
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