[CAS NO. 1048371-03-4] UPF 1069
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PRODUCTS SPECIFICATIONS [1048371-03-4]
Store
Catalog
SLK-S8038
Brand
Selleck
CAS
1048371-03-4
DESCRIPTION [1048371-03-4]
Overview
| MDL | MFCD14051631 |
|---|---|
| Molecular Weight | 279.29 |
| Molecular Formula | C17H13NO3 |
| SMILES | O=C1NC=CC2=C1C=CC=C2OCC(C3=CC=CC=C3)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5805 mL | 17.9025 mL | 35.8051 mL |
| 5 mM | 0.7161 mL | 3.5805 mL | 7.1610 mL |
| 10 mM | 0.3581 mL | 1.7903 mL | 3.5805 mL |
| 50 mM | 0.0716 mL | 0.3581 mL | 0.7161 mL |
Description
UPF 1069 is a selective inhibitor with of 0.3 μM. It is ~27-fold selective against PARP1.
Features
The most selective PARP2 inhibitor available to date.
In vitro
UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM while inhibiting PARP1 with IC50 of 8 μM.
In vivo
In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.
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