[CAS NO. 7497-07-6] NSC 405020
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PRODUCTS SPECIFICATIONS [7497-07-6]
Store
Catalog
SLK-S8072
Brand
Selleck
CAS
7497-07-6
DESCRIPTION [7497-07-6]
Overview
| MDL | MFCD02006898 |
|---|---|
| Molecular Weight | 260.16 |
| Molecular Formula | C12H15Cl2NO |
| SMILES | O=C(NC(CCC)C)C1=CC=C(Cl)C(Cl)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
NSC 405020 is a noncatalytic inhibitor of , directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP.
Targets
| MT1-MMP [1] |
In vitro
NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP. NSC 405020 affects PEX homodimerization but not catalytic activity of MT1-MMP. NSC 405020 (100μM) inhibits migration of cells with high level of MT1-MMP, with a reduction of migration efficiency by about 75%. NSC 405020 does not inhibit migration of cells with low level of MT1-MMP and does not inhibit cell adhesion on collagen.
In vivo
NSC 405020 (0.5 mg/kg, intratumoral injection) significantly represses tumor growth. NSC 405020 causes a fibrotic, ΔPEX-like tumor phenotype and increases the level of COL-I.
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