[CAS NO. 328541-79-3] GlyH-101
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PRODUCTS SPECIFICATIONS [328541-79-3]
Store
Catalog
SLK-S8094
Brand
Selleck
CAS
328541-79-3
DESCRIPTION [328541-79-3]
Overview
| MDL | MFCD01532954 |
|---|---|
| Molecular Weight | 493.15 |
| Molecular Formula | C19H15Br2N3O3 |
| SMILES | O=C(N/N=C/C1=CC(Br)=C(O)C(Br)=C1O)CNC2=CC=C3C=CC=CC3=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0278 mL | 10.1389 mL | 20.2778 mL |
| 5 mM | 0.4056 mL | 2.0278 mL | 4.0556 mL |
| 10 mM | 0.2028 mL | 1.0139 mL | 2.0278 mL |
| 50 mM | 0.0406 mL | 0.2028 mL | 0.4056 mL |
Description
GlyH-101 is a selective and reversible inhibitor with of 4.3 μM.
Targets
| CFTR [1] |
| 4.3 μM(Ki) |
In vitro
GlyH-101 reversibly inhibits CFTR Cl- conductance in <1 min. In rabbit isolated ventricular myocytes, GlyH-101 also blocks cardiac I(Cl.PKA) channels. In transfected FRT (SLC26A9-FRT) cells, GlyH-101 inhibits SLC26A9-mediated Cl- currents.
In vivo
In mice, Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibits forskolin-induced hyperpolarization in nasal potential differences. In a cholera model, intraluminal GlyH-101 (2.5 μg) reduces cholera toxin-induced intestinal fluid secretion by approximately 80%.
References
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