[CAS NO. 1198097-97-0] Mirin
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PRODUCTS SPECIFICATIONS [1198097-97-0]
Store
Catalog
SLK-S8096
Brand
Selleck
CAS
1198097-97-0
DESCRIPTION [1198097-97-0]
Overview
| MDL | MFCD05885480 |
|---|---|
| Molecular Weight | 220.25 |
| Molecular Formula | C10H8N2O2S |
| SMILES | O=C1N=C(N)S/C1=C\C2=CC=C(O)C=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.5403 mL | 22.7015 mL | 45.4030 mL |
| 5 mM | 0.9081 mL | 4.5403 mL | 9.0806 mL |
| 10 mM | 0.4540 mL | 2.2701 mL | 4.5403 mL |
| 50 mM | 0.0908 mL | 0.4540 mL | 0.9081 mL |
Description
Mirin is a potent Mre11–Rad50–Nbs1 () complex inhibitor, and inhibits Mre11-associated exonuclease activity. Mirin inhibits MRN-dependent activation of ATM.
In vitro
Mirin inhibits DSB-induced ATM activation, the ATM-dependent phosphorylation of the downstream targets Nbs1 and Chk2 and the MRN-dependent autophosphorylation of ATM at Ser1981 in response to DSBs. Mirin also inhibits the G2 checkpoint in TOSA4 cells, and homology-dependent DNA repair in HEK293 cells. In cells with integrated HPV16 (SiHa), Mirin sensitizes HPV episomes to PA25 resulting in a ∼5-fold reduction of the PA25 IC50. Pretreatment with mirin also decreases cell viability and inhibits proliferating cell nuclear antigen expression in cisplatin-treated human embryonic kidney 293 cells.
References
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