[CAS NO. 853299-07-7] K03861

Name: K03861
Brand: Arctom Scientific
SKU: SLK-S8100

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PRODUCTS SPECIFICATIONS [853299-07-7]

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Catalog

SLK-S8100

Brand

Selleck

CAS

853299-07-7

DESCRIPTION [853299-07-7]

Overview

MDL	MFCD19443769
Molecular Weight	501.50
Molecular Formula	C24H26F3N7O2
SMILES	O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)NC3=CC=C(OC4=NC(N)=NC=C4)C=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9940 mL	9.9701 mL	19.9402 mL
5 mM	0.3988 mL	1.9940 mL	3.9880 mL
10 mM	0.1994 mL	0.9970 mL	1.9940 mL
50 mM	0.0399 mL	0.1994 mL	0.3988 mL

Description

K03861 (AUZ 454，AUZ454) is a type II inhibitor with of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.

Targets

CDK2(C118L/A144C) ^[1] (Cell-free assay)	CDK2(A144C) ^[1] (Cell-free assay)	CDK2(C118L) ^[1] (Cell-free assay)	CDK2(WT) ^[1] (Cell-free assay)
9.7 nM(Kd)	15.4 nM(Kd)	18.6 nM(Kd)	50 nM(Kd)

In vitro

K03861 inhibits CDK2 activity by competing with binding of activating cyclins.

References

[1] Alexander LT, et al. ACS Chem Biol. 2015, 10(9), 2116-2125.