[CAS NO. 1542705-92-9] CB-5083
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PRODUCTS SPECIFICATIONS [1542705-92-9]
Store
Catalog
SLK-S8101
Brand
Selleck
CAS
1542705-92-9
DESCRIPTION [1542705-92-9]
Overview
| MDL | MFCD28963914 |
|---|---|
| Molecular Weight | 413.47 |
| Molecular Formula | C24H23N5O2 |
| SMILES | O=C(C1=CC=CC2=C1C=C(C)N2C3=NC(NCC4=CC=CC=C4)=C(COCC5)C5=N3)N |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4186 mL | 12.0928 mL | 24.1856 mL |
| 5 mM | 0.4837 mL | 2.4186 mL | 4.8371 mL |
| 10 mM | 0.2419 mL | 1.2093 mL | 2.4186 mL |
| 50 mM | 0.0484 mL | 0.2419 mL | 0.4837 mL |
Description
CB-5083 is a potent, selective, and orally bioavailable inhibitor with of 11 nM. Phase 1.
Targets
| p97 AAA ATPase [1] (Cell-free assay) |
| 11 nM |
In vitro
In A549 cells, CB-5083 causes significant K48 poly-ubiquitinated protein and CHOP accumulation as well as p62 reduction, and kills tumor cells with IC50 of 680 nM.
In vivo
In mice bearing human HCT 116 colon tumor xenografts, CB-5083 (75 mg/kg, p.o.) significantly inhibits tumor growth. In mice bearing established human AMO-1 multiple myeloma and A549 lung carcinoma tumor xenografts, CB-5083 (100 mg/kg, p.o.) also results in significant tumor growth inhibition.
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