[CAS NO. 300817-68-9] BH3I-1

Name: BH3I-1
Brand: Arctom Scientific
SKU: SLK-S8177

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [300817-68-9]

Store

Catalog

SLK-S8177

Brand

Selleck

CAS

300817-68-9

DESCRIPTION [300817-68-9]

Overview

MDL	MFCD03453544
Molecular Weight	400.31
Molecular Formula	C15H14BrNO3S2
SMILES	O=C(O)C(C(C)C)N(C/1=O)C(SC1=C\C2=CC=C(Br)C=C2)=S

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4981 mL	12.4903 mL	24.9806 mL
5 mM	0.4996 mL	2.4981 mL	4.9961 mL
10 mM	0.2498 mL	1.2490 mL	2.4981 mL
50 mM	0.0500 mL	0.2498 mL	0.4996 mL

Description

BH3I-1 is a inhibitor with Ki of 2.4 μM (by fluorescence polarization ).It is a selective inhibitor of family proteins.

Targets

BH3-Bcl-xL interaction ^[1]	p53/MDM2 ^[2]
2.4 μM(Ki)	5.3 μM(Kd)

In vitro

BH3I-1 inhibits Bcl-xL heterodimerization in vitro. It also induces cytochrome c release. BH3I-1, while inhibiting its reported target Bcl-2/Bim and Bcl-xL/Bim, shows significant inhibition of both the p53/hDM2 and p300/Hif-1a interactions.

References

[1] Degterev A, et al. Nat Cell Biol. 2001, 3(2):173-82.
[2] Porter JR, et al. Chem Commun (Camb). 2010, 46(42):8020-2.