[CAS NO. 1384426-12-3] NT157
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PRODUCTS SPECIFICATIONS [1384426-12-3]
Store
Catalog
SLK-S8228
Brand
Selleck
CAS
1384426-12-3
DESCRIPTION [1384426-12-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 412.26 |
| Molecular Formula | C16H14BrNO5S |
| SMILES | C1=C(C=C(C(=C1O)O)O)CNC(=S)C=CC2=CC(=C(C(=C2)Br)O)O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4257 mL | 12.1283 mL | 24.2565 mL |
| 5 mM | 0.4851 mL | 2.4257 mL | 4.8513 mL |
| 10 mM | 0.2426 mL | 1.2128 mL | 2.4257 mL |
| 50 mM | 0.0485 mL | 0.2426 mL | 0.4851 mL |
Description
NT157, a selective inhibitor of , has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival.
Targets
| IRS1/2 [2] |
In vitro
NT157 treatment resulted in dose-dependent inhibition of IGF1R activation, suppression of IRS protein expression, inhibition of IGF1-induced AKT activation, but increased ERK activation in NT157-treated cells in vitro. These effects were correlated with decreased proliferation and increasing apoptosis of LNCaP cells and increasing G2-M arrest in PC3 cells. NT157 can mediate suppression of IGF1R-mediated survival signaling through the established mechanism for negative feedback of IGF1R signaling: targeting IRS1/2 for serine phosphorylation and subsequent degradation. NT157 displayed little to no effect on the survival of normal melanocytes and fibroblasts.
In vivo
NT157 suppressed androgen-responsive growth, delayed CRPC progression of LNCaP xenografts, and suppressed PC3 tumor growth alone and in combination with docetaxel. Melanoma tumor growth and metastasis is efficiently inhibited by NT157.
References
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