[CAS NO. 472981-92-3] SB366791
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PRODUCTS SPECIFICATIONS [472981-92-3]
Store
Catalog
SLK-S8238
Brand
Selleck
CAS
472981-92-3
DESCRIPTION [472981-92-3]
Overview
| MDL | MFCD01033818 |
|---|---|
| Molecular Weight | 287.74 |
| Molecular Formula | C16H14ClNO2 |
| SMILES | N(C(C=CC1=CC=C(Cl)C=C1)=O)C2=CC(OC)=CC=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4754 mL | 17.3768 mL | 34.7536 mL |
| 5 mM | 0.6951 mL | 3.4754 mL | 6.9507 mL |
| 10 mM | 0.3475 mL | 1.7377 mL | 3.4754 mL |
| 50 mM | 0.0695 mL | 0.3475 mL | 0.6951 mL |
Description
SB-366791 is a novel, potent, and selective, cinnamide antagonist with an IC50 of 5.7 nM.
Targets
| TRPV1 [1] (Cell-based assay) |
| 5.7 nM |
In vitro
SB-366791 is a structurally novel and potent TRPV1 antagonist which is capable of inhibiting the capsaicin-, acid- and heat-mediated activation of the receptor but produces little or no effect on a wide range of enzymes, ion channels, GPCRs and other proteins. SB-366791 may prove to be a better tool for unambiguously defining the (patho)physiological role of TRPV1.
In vivo
the TRPV1 antagonist SB366791 reduces the number of flinches but did not improve ambulation and weight-bearing. A sub-analgesic dose of SB366791 potentiates the effects of morphine at doses of
3.0 and 10.0 mg/kg on flinches and weight-bearing but not ambulation. The combination of morphine and SB366791 has potent analgesic effects on bone cancer pain.
References
Synonyms
2-Propenamide, 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-
3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
SB 366791
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