[CAS NO. 1429749-41-6] Thiomyristoyl
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PRODUCTS SPECIFICATIONS [1429749-41-6]
Store
Catalog
SLK-S8245
Brand
Selleck
CAS
1429749-41-6
DESCRIPTION [1429749-41-6]
Overview
| MDL | MFCD30738003 |
|---|---|
| Molecular Weight | 581.85 |
| Molecular Formula | C34H51N3O3S |
| SMILES | O=C(OCC1=CC=CC=C1)N[C@@H](CCCCNC(CCCCCCCCCCCCC)=S)C(NC2=CC=CC=C2)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7187 mL | 8.5933 mL | 17.1866 mL |
| 5 mM | 0.3437 mL | 1.7187 mL | 3.4373 mL |
| 10 mM | 0.1719 mL | 0.8593 mL | 1.7187 mL |
| 50 mM | 0.0344 mL | 0.1719 mL | 0.3437 mL |
Description
Thiomyristoyl (TM) is a potent and specific inhibitor with an of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.
Targets
| SIRT2 [1] (Cell-free assay) |
| 28 nM |
In vitro
Thiomyristoyl(TM) is a highly selective SIRT2 inhibitor. It cannot efficiently inhibit SIRT3, SIRT5, SIRT6, or SIRT7. In vitro, it shows great inhibition of cell viability and its cytotoxicity is relatively selective toward cancer cells. TM decreases c-Myc oncoprotein level in cancer cells, the ability of TM to decrease c-Myc abundance in different cell lines correlates with the sensitivity of the cell lines to TM.
In vivo
The anticancer effect of TM correlates with its ability to decrease c-Myc level. TM has limited effects on non-cancerous cells and tumor-free mice.
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