[CAS NO. 1070773-09-9] RK-33
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [1070773-09-9]
Store
Catalog
SLK-S8246
Brand
Selleck
CAS
1070773-09-9
DESCRIPTION [1070773-09-9]
Overview
| MDL | MFCD30489740 |
|---|---|
| Molecular Weight | 428.44 |
| Molecular Formula | C23H20N6O3 |
| SMILES | O=C1N(CC2=CC=C(OC)C=C2)C3=NC=NC4=C(N=CN4CC5=CC=C(OC)C=C5)C3=N1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3340 mL | 11.6702 mL | 23.3405 mL |
| 5 mM | 0.4668 mL | 2.3340 mL | 4.6681 mL |
| 10 mM | 0.2334 mL | 1.1670 mL | 2.3340 mL |
| 50 mM | 0.0467 mL | 0.2334 mL | 0.4668 mL |
Description
RK-33 is a first-in-class small molecule inhibitor of (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
Targets
| DDX3 [1] |
In vitro
RK-33 binds specifically to DDX3, but not to the closely related proteins DDX5 and DDX17. RK-33 inhibits cancer growth and radiosensitizes lung cancer cells in a DDX3-dependent manner. RK-33 has no effect on either mitochondrial respiration or ATP generation. RK-33 curbs proliferation and induces apoptosis in a DDX3-dependent fashion. Wnt signaling is mediated by DDX3 and inhibited by RK-33. RK-33 impairs radiation-induced DNA damage repair by inhibiting NHEJ activity.
In vivo
RK-33 in combination with radiation induces tumor regression in multiple mouse models of lung cancer. RK-33, at the dose used, is non-toxic in SCID mice. RK-33-treated mice do not exhibit any discernable morphological changes.
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.