[CAS NO. 1353550-13-6] Olmutinib (BI 1482694)

Name: Olmutinib (BI 1482694)
Brand: Arctom Scientific
SKU: SLK-S8294

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PRODUCTS SPECIFICATIONS [1353550-13-6]

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Catalog

SLK-S8294

Brand

Selleck

CAS

1353550-13-6

DESCRIPTION [1353550-13-6]

Overview

MDL	MFCD29918158
Molecular Weight	486.59
Molecular Formula	C26H26N6O2S
SMILES	O(C1=C2C(=NC(NC3=CC=C(C=C3)N4CCN(C)CC4)=N1)C=CS2)C5=CC(NC(C=C)=O)=CC=C5

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.0551 mL	10.2756 mL	20.5512 mL
5 mM	0.4110 mL	2.0551 mL	4.1102 mL
10 mM	0.2055 mL	1.0276 mL	2.0551 mL
50 mM	0.0411 mL	0.2055 mL	0.4110 mL

Description

Olmutinib (BI 1482694) is a novel third-generation mutation-specific tyrosine kinase inhibitor (TKI). Also a potent inhibitor of .

Targets

mutant EGFR ^[1]	BTK ^[2] (Cell-free assay)
	13.9 nM

In vitro

HM61713 causes potent inhibition in cell lines H1975 (L858R and T790M) and HCC827 (exon 19 deletion). It has a low potency for NSCLC cell line H358 harboring wild-type EGFR (GI50 of 2225 nM).

In vivo

HM61713 has a half-life of over 24 h for EGFR inhibition. In the in vivo studies of xenograft models with grafts of H1975 and HCC827, HM61713 is active against the tumors without showing any side effects.

References

[1] Wang S, et al. J Hematol Oncol. 2016, 9: 34.
[2] Qiumeng Zhang, et al. RSC Advances. 2017, 7:26060.

Synonyms

2-Propenamide, N-[3-[[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-

N-[3-[[2-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide

Olmutinib

HM 61713

BI 1482694