[CAS NO. 113104-25-9] NSC228155
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PRODUCTS SPECIFICATIONS [113104-25-9]
Store
Catalog
SLK-S8312
Brand
Selleck
CAS
113104-25-9
DESCRIPTION [113104-25-9]
Overview
| MDL | MFCD30742994 |
|---|---|
| Molecular Weight | 290.25 |
| Molecular Formula | C11H6N4O4S |
| SMILES | [O-][N+]1=CC=CC=C1SC2=CC=C(C3=NON=C32)[N+]([O-])=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4453 mL | 17.2265 mL | 34.4531 mL |
| 5 mM | 0.6891 mL | 3.4453 mL | 6.8906 mL |
| 10 mM | 0.3445 mL | 1.7227 mL | 3.4453 mL |
| 50 mM | 0.0689 mL | 0.3445 mL | 0.6891 mL |
Description
NSC228155 is an activator of . It binds to the sEGFR dimerization domain II and modulates EGFR tyrosine phosphorylation.
In vitro
NSC 228155 promotes transactivation of several RTKs, including ErbB2 and ErbB3, Insulin R and IGF-1 R receptors in the cells. It stimulates dimerization of sEGFR domain II. NSC 228155 can rapidly move across cell membranes and disperse within both cytoplasmic and nuclear compartments. It rapidly generates hydrogen peroxide within cells. NSC 228155 is also a potent inhibitor of KIX-KID interaction(IC50 = 0.36 μM), but it is not particularly selective against CREB-mediated gene transcription in HEK 293T cells.
References
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