[CAS NO. 1054543-47-3] Apoptozole
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PRODUCTS SPECIFICATIONS [1054543-47-3]
Store
Catalog
SLK-S8365
Brand
Selleck
CAS
1054543-47-3
DESCRIPTION [1054543-47-3]
Overview
| MDL | MFCD19443178 |
|---|---|
| Molecular Weight | 625.56 |
| Molecular Formula | C33H25F6N3O3 |
| SMILES | O=C(N)C1=CC=C(CN2C(C3=CC=C(OC)C=C3)=C(C4=CC=C(OC)C=C4)N=C2C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)C=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
Apoptozole (Apoptosis Activator VII) is an inhibitor of and with dissociation constants Kd of 0.14 μM and 0.21 μM, respectively. It induces caspase-dependent apoptosis.
In vitro
Apoptozole induces caspase dependent apoptosis by blocking interaction of HSP70 with APAF-1, without affecting interactions of HSP70 with ASK1, JNK, BAX, and AIF. However, apoptozole may form aggregates under aqueous conditions that could interact with HSP70 proteins in a non-specific manner, potentially leading to false positives and inconsistent data.
In vivo
Apoptozole greatly retards tumor growth in mice xenografted with cancer cells without affecting mouse viability. The elimination half-life time (T) of Az in blood is found to be significantly longer than that of Dox (8.04 versus 1.60 hr) and the time needed to reach a maximum concentration (Tmax) of Az is shorter than that of Dox (1.00 versus 4.00 hr).
References
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