[CAS NO. 1821428-35-6] AZD0156
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PRODUCTS SPECIFICATIONS [1821428-35-6]
Store
Catalog
SLK-S8375
Brand
Selleck
CAS
1821428-35-6
DESCRIPTION [1821428-35-6]
Overview
| MDL | MFCD30470661 |
|---|---|
| Molecular Weight | 461.56 |
| Molecular Formula | C26H31N5O3 |
| SMILES | O=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=C(OCCCN(C)C)N=C5)=CC=C4N=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1666 mL | 10.8328 mL | 21.6657 mL |
| 5 mM | - | - | - |
| 10 mM | - | - | - |
| 50 mM | - | - | - |
Description
AZD0156 is a potent and selective inhibitors of , with potential chemo-/radio-sensitizing and antineoplastic activities. AZD0156 prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells.
Targets
| ATM [1] |
In vitro
AZD0156 shows sub-nanomolar potency in cell based assays of ATM inhibition with selectivities of greater than 1000 fold over other members of the PIKK family of enzymes.
In vivo
AZD0156 is a permeable, highly soluble compound with excellent preclinical pharmacokinetic properties including oral bioavailability. AZD0156 shows robust efficacy in mouse xenograft models after oral administration when combined with DSB inducing agents. AZD0156 is currently undergoing early clinical assessment.
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