[CAS NO. 2029049-79-2] ML390
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PRODUCTS SPECIFICATIONS [2029049-79-2]
Store
Catalog
SLK-S8382
Brand
Selleck
CAS
2029049-79-2
DESCRIPTION [2029049-79-2]
Overview
| MDL | MFCD30489750 |
|---|---|
| Molecular Weight | 406.4 |
| Molecular Formula | C21H21F3N2O3 |
| SMILES | O=C(NCCC(N[C@@H]1CCCC2=C1C=CC=C2)=O)C3=CC=C(OC(F)(F)F)C=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4606 mL | 12.3031 mL | 24.6063 mL |
| 5 mM | 0.4921 mL | 2.4606 mL | 4.9213 mL |
| 10 mM | 0.2461 mL | 1.2303 mL | 2.4606 mL |
| 50 mM | 0.0492 mL | 0.2461 mL | 0.4921 mL |
Description
ML390 is a human inhibitor with an IC50 of 0.56 μM and induces differentiation in acute myeloid leukemia.
Targets
| DHODH [1] (Cell-free assay) |
| 0.56 μM |
In vitro
ML390 was active with an ED50 (effective concentration triggering 50% of its maximal differentiation activity) of 2 μM in murine and human AML cell lines, offering insight into the mechanism of overcoming differentiation arrest. DHODH inhibitors demonstrated effective at prolonging survival in animal models of leukemia.
References
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