[CAS NO. 1374743-00-6] Trilaciclib (G1T28)
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PRODUCTS SPECIFICATIONS [1374743-00-6]
Store
Catalog
SLK-S8389
Brand
Selleck
CAS
1374743-00-6
DESCRIPTION [1374743-00-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 446.55 |
| Molecular Formula | C24H30N8O |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2394 mL | 11.1970 mL | 22.3939 mL |
| 5 mM | - | - | - |
| 10 mM | - | - | - |
| 50 mM | - | - | - |
Description
Trilaciclib (G1T28, G1T28-1) is a highly potent, selective and reversible inhibitor. Trilaciclib inhibits and with IC50 of 1 nM and 4 nM, respectively.
In vitro
G1T28 is a potent and selective CDK4/6 inhibitor that inhibits the phosphorylation of RB and induces an exclusive, reversible G1 arrest. In vitro and in vivo, G1T28 protects RB competent cells from damage by chemotherapy as assessed by gamma-H2A.X (γH2AX) and apoptosis through caspase 3/7 activation.
References
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