[CAS NO. 18228-17-6] KG-501 (2-naphthol-AS-E-phosphate)

Name: KG-501 (2-naphthol-AS-E-phosphate)
Brand: Arctom Scientific
SKU: SLK-S8409

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PRODUCTS SPECIFICATIONS [18228-17-6]

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Catalog

SLK-S8409

Brand

Selleck

CAS

18228-17-6

DESCRIPTION [18228-17-6]

Overview

MDL	-
Molecular Weight	377.72
Molecular Formula	C17H13ClNO5P
SMILES	C(NC1=CC=C(Cl)C=C1)(=O)C=2C(OP(=O)(O)O)=CC3=C(C2)C=CC=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.6475 mL	13.2373 mL	26.4746 mL
5 mM	0.5295 mL	2.6475 mL	5.2949 mL
10 mM	0.2647 mL	1.3237 mL	2.6475 mL
50 mM	0.0529 mL	0.2647 mL	0.5295 mL

Description

KG-501 (2-naphthol-AS-E-phosphate) is a inhibitor that disrupts CREB-dependent transcription (Ki = 10 μM) and CREB:CBP interaction (Ki = 50 μM). It also disrupts phospho (Ser-133) CREB binding to KIX with a Ki of ≈90 μM, using concentrations of CREB that were within the linear range of the binding assay.

Targets

CREB ^[1]

In vitro

KG-501 inhibits induction of cAMP-responsive genes, at least in part, by blocking the CREB:CBP interaction. The inhibition of the CREB pathway using KG-501, induces an inhibition of neurite outgrowth and synaptogenesis, as well as a decrease of MAP2+ neuronal cells.

References

[1] Jennifer L. Best, et al. Proc Natl Acad Sci U S A. 2004, 101(51): 17622–17627.
[2] Pistollato F, et al. Toxicol Appl Pharmacol. 2014, 280(2):378-88.
[3] Bin Cao, et al. Int J Clin Exp Pathol. 2016, 9(12):12551-12558.

Synonyms

2-Naphthalenecarboxamide, N-(4-chlorophenyl)-3-(phosphonooxy)-

2-Naphthanilide, 4′-chloro-3-hydroxy-, dihydrogen phosphate (ester)

2-Naphthanilide, 4′-chloro-3-hydroxy-, phosphate

N-(4-Chlorophenyl)-3-(phosphonooxy)-2-naphthalenecarboxamide

Naphthol AS-E phosphate

KG 501