[CAS NO. 1290541-46-6] B02
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PRODUCTS SPECIFICATIONS [1290541-46-6]
Store
Catalog
SLK-S8434
Brand
Selleck
CAS
1290541-46-6
DESCRIPTION [1290541-46-6]
Overview
| MDL | MFCD03294274 |
|---|---|
| Molecular Weight | 339.39 |
| Molecular Formula | C22H17N3O |
| SMILES | O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CC=CN=C3)=NC4=C1C=CC=C4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9465 mL | 14.7323 mL | 29.4646 mL |
| 5 mM | 0.5893 mL | 2.9465 mL | 5.8929 mL |
| 10 mM | 0.2946 mL | 1.4732 mL | 2.9465 mL |
| 50 mM | 0.0589 mL | 0.2946 mL | 0.5893 mL |
Description
B02 is a small-molecule inhibitor of human with an of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).
Targets
| RAD51 [2] (Cell-free assay) |
| 27.4 μM |
In vitro
B02 is a specific inhibitor of human RAD51 recombinase, blocks HR repair in human embryonic kidney (HEK) and breast cancer cells and increases their sensitivity to a wide range of DNA damaging agents. Also, B02 enhances DNA damage and apoptosis induced by decitabine in MM cells. B02 shows high specificity for RAD51 and does not significantly inhibit RAD54 in the range of concentrations from 0 to 200 μM. B02 shows biological effect in human and mouse cells. In human embryonic kidney (HEK) cells, B02 disrupts RAD51 foci formation in response to DNA damage and inhibited DSB repair and DSB-dependent HR. B02 can also increase the sensitivity of cancer cells to chemotherapeutic DNA damaging agents.
In vivo
B02 significantly increases the anti-tumor activity of cisplatin in vivo. B02 is tolerated by mice at doses up to 50 mg/kg without obvious body weight loss. No detectable morphological changes induced by B02 in kidneys and livers, main organs for detoxification are found.
References
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