[CAS NO. 662163-81-7] Importazole
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PRODUCTS SPECIFICATIONS [662163-81-7]
Store
Catalog
SLK-S8446
Brand
Selleck
CAS
662163-81-7
DESCRIPTION [662163-81-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 318.42 |
| Molecular Formula | C20H22N4 |
| SMILES | CC(NC1=C2C=CC=CC2=NC(N3CCCC3)=N1)C4=CC=CC=C4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1405 mL | 15.7025 mL | 31.4051 mL |
| 5 mM | 0.6281 mL | 3.1405 mL | 6.2810 mL |
| 10 mM | 0.3141 mL | 1.5703 mL | 3.1405 mL |
| 50 mM | 0.0628 mL | 0.3141 mL | 0.6281 mL |
Description
Importazole is a small molecule inhibitor of the specifically blocking importin-β-mediated nuclear import. Importazole induces and inhibits tumor growth.
Targets
| importin-β [1] |
In vitro
Importazole is an effective inhibitor of the Ran/importin-β interaction in vitro. Importazole specifically blocks importin-β-mediated nuclear import both in Xenopus egg extracts and cultured cells, without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export. When added during mitosis, importazole impairs the release of an importin-β cargo FRET probe and causes both predicted and novel defects in spindle assembly. It also inhibits proliferation and induces apoptosis of multiple myeloma cells by blocking the NF-κB signal pathway in vitro.
References
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